Journal of Natural Remedies

G. S. Chakraborthy ¹, Pinkal Patel ¹, Sachin Sharma ¹, Rupal K. Jani ¹, Snigdha Das Mandal ¹

Affiliations
1 Faculty of Pharmacy, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat, IN

Abstract

Herbs have been used to treat various diseases in one form or another for the betterment of mankind since the ancient ages. As a result of this usage, the situation gradually deteriorated due to overexploitation, resulting in a decrease in natural resource production. Looking in to the benefits, the flora and fauna were rehabilitees through tissue culture, conservation, plantation and other means to ensure their availability in their natural form. Nature is the best chemist, as it aids in the treatment of ailments and provides the results of them. It is impossible to find any plant that has no medical use. Ulcer and liver diseases are at an alarming rate in the developing countries. A number of drugs, which are in the existing medications for peptic ulcer and hepatic diseases, are on the comeback list due to their adverse effects and drug interactions. Drugs, which are derived from the flora, have an important role in treatment and show a higher rate of acceptance. Flavonoids are the naturally occurring, low-molecular-weight molecules seen mostly distributed in the vegetable kingdom and hold an utmost thurst in declining the generation of reactive oxygen species. Secondary compounds like apigenin, sylimarin, genesis, quercetin, kaempherol and catechins have a significant role in these diseases. This article focuses on the importance of flavonoids, which can serve as potent anti-ulcer and hepatoprotective agents.

Keywords

Flavonoids, Herbs, Liver, Secondary Metabolites, Ulcer.

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Janki B. Patel ¹, Mansi Gajera ¹, Zalak Shah ¹, Pinkal Patel ¹, Kinjal Parmar ¹, Vaishali Patel ¹, Hetvi Patel ¹, Disha Patel ¹, Kanupriya Rathore ¹

Affiliations
1 Faculty of Pharmacy, Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat, IN

Abstract

The goals of the current studies were to create herbal excipients-based ketoconazole cream to enhance the efficacy against chronic mucocutaneous candidiasis. Ketoconazole, coconut oil and other herbal excipients namely shea butter, bees wax, Lanolin and Rose oil were used for the formulation. Each formulation was prepared with various concentrations of coconut oil. Every prepared formulations were evaluated successfully. Among all the formulations F4 was the best that exhibiting a higher in vitro diffusion rate 59.6 ± 0.10 % CDR within 480 min with maximum antifungal efficacy, compared with the marketed formulation. We might therefore say that herbal excipients-based cream improved patient compliance and is a superior alternative to oral preparation, easier administration, local bioavailability, and better results for individuals with persistent mucocutaneous candidiasis who are afflicted with fungi.

Keywords

Anti-Fungal Activity, Cream Formulation, Coconut Oil, Herbal Excipients, Ketoconazole, Shea Butter

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